Article
Mitochondrial DNA in pathogenesis of Alzheimer's and Parkinson's diseases.
Acta neurobiologiae experimentalis - 1 Jan 2006
Maruszak Aleksandra, Gaweda-Walerych Katarzyna, Sołtyszewski Ireneusz, Zekanowski Cezary
Abstract excerpt
A critical role of mitochondrial dysfunction and oxidative damage has been implicated in etiopathology of many neurodegenerative disorders, as well as in normal aging. Alzheimer's and Parkinson's diseases are common devastating late-onset neurodegenerative disorders, associated with mitochondrial DNA variations, which are suggested to affect mitochondrial functions. This paper reviews the current knowledge on the...
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