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The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function

9 Jan 2018

Abstract excerpt

The gene encoding for transcription factor 7-like 2 (TCF7L2) is the strongest type 2 diabetes mellitus (T2DM) candidate gene discovered to date. The TCF7L2 protein is a key transcriptional effector of the Wnt/β-catenin signaling pathway, which is an important developmental pathway that negatively regulates adipogenesis. However, the precise role that TCF7L2 plays in the development and function of adipocytes...

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PMID: 29317436
DOI: 10.2337/db17-0318

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