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Characterization of SARS-CoV-2 replication complex elongation and proofreading activity

10 Jun 2022

Abstract excerpt

The replication complex (RC) of SARS-CoV-2 was recently shown to be one of the fastest RNA-dependent RNA polymerases of any known coronavirus. With this rapid elongation, the RC is more prone to incorporate mismatches during elongation, resulting in a highly variable genomic sequence. Such mutations render the design of viral protein targets difficult, as drugs optimized for a given viral protein sequence can...

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PMID: 35688849
DOI: 10.1038/s41598-022-13380-1

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