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Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex

1 Oct 2021

Abstract excerpt

Remdesivir (RDV), a nucleotide analog with broad-spectrum features, has exhibited effectiveness in COVID-19 treatment. However, the precise working mechanism of RDV when targeting the viral RNA-dependent RNA polymerase (RdRP) has not been fully elucidated. Here, we solve a 3.0-Å structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRP elongation complex (EC) and assess RDV intervention in...

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PMID: 34653416
DOI: 10.1016/j.celrep.2021.109882

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