Article
The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression.
Science advances - 10 Jun 2022
Yang Han, Ting Xia, Geng Yue-Hang, Xie Yuntao, Nierenberg Jovia L, Huo Yan-Fei, Zhou Yan-Ting, Huang Yang, Yu Yu-Qing, Yu Xin-Yao, Li Xiao-Fei, Ziv Elad, Zhang Hongquan, Fang Wei-Gang, Shen Yin, Tian Xin-Xia
Abstract excerpt
Most genome-wide association study (GWAS)-identified breast cancer-associated causal variants remain uncharacterized. To provide a framework of understanding GWAS-identified variants to function, we performed a comprehensive study of noncoding regulatory variants at the NTN4 locus (12q22) and NTN4 gene in breast cancer etiology. We find that rs11836367 is the more likely causal variant, disrupting enhancer...
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