Article
eQTL Colocalization Analyses Identify NTN4 as a Candidate Breast Cancer Risk Gene.
American journal of human genetics - 1 Oct 2020
Beesley Jonathan, Sivakumaran Haran, Moradi Marjaneh Mahdi, Shi Wei, Hillman Kristine M, Kaufmann Susanne, Hussein Nehal, Kar Siddhartha, Lima Luize G, Ham Sunyoung, Möller Andreas, Chenevix-Trench Georgia, Edwards Stacey L, French Juliet D
Abstract excerpt
Breast cancer genome-wide association studies (GWASs) have identified 150 genomic risk regions containing more than 13,000 credible causal variants (CCVs). The CCVs are predominantly noncoding and enriched in regulatory elements. However, the genes underlying breast cancer risk associations are largely unknown. Here, we used genetic colocalization analysis to identify loci at which gene expression could...
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