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Article

Cerebral Organoids for Modeling of HSV-1-Induced-Amyloid β Associated Neuropathology and Phenotypic Rescue.

International journal of molecular sciences - 26 May 2022

Qiao Haowen, Zhao Wen, Guo Moujian, Zhu Lili, Chen Tao, Wang Jibo, Xu Xiaodong, Zhang Zhentao, Wu Ying, Chen Pu

Abstract excerpt

Herpes simplex virus type I (HSV-1) infection is a potential risk factor involved in the Amyloid β (Aβ) associated neuropathology. However, further understanding of the neuropathological effects of the HSV-1 infection is hampered by the limitations of existing infection models due to the distinct differences between human brains and other mammalians' brains. Here we generated cerebral organoid models derived from...

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Identifiers

PMID: 35682661
DOI: 10.3390/ijms23115981
PMCID: PMC9181143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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