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Article

Molecular Classification and Overcoming Therapy Resistance for Acute Myeloid Leukemia with Adverse Genetic Factors.

International journal of molecular sciences - 25 May 2022

Ikeda Daisuke, Chi SungGi, Uchiyama Satoshi, Nakamura Hirotaka, Guo Yong-Mei, Yamauchi Nobuhiko, Yuda Junichiro, Minami Yosuke

Abstract excerpt

The European LeukemiaNet (ELN) criteria define the adverse genetic factors of acute myeloid leukemia (AML). AML with adverse genetic factors uniformly shows resistance to standard chemotherapy and is associated with poor prognosis. Here, we focus on the biological background and real-world etiology of these adverse genetic factors and then describe a strategy to overcome the clinical disadvantages in terms of...

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Identifiers

PMID: 35682627
DOI: 10.3390/ijms23115950
PMCID: PMC9180585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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