Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers.

Scientific reports - 20 Jan 2020

Malouf Gabriel G, Flippot Ronan, Dong Yiyu, Dinatale Renzo G, Chen Ying-Bei, Su Xiaoping, Compérat Eva, Rouprêt Morgan, Mano Roy, Blum Kyle A, Yao Hui, Mouawad Roger, Spano Jean-Philippe, Khayat David, Karam Jose A, Ho Thai H, Tickoo Satish K, Russo Paul, Hsieh James J, Tannir Nizar M, Hakimi Abraham A

Abstract excerpt

Sarcomatoid clear-cell renal cell carcinomas (sRCC) are associated with dismal prognosis. Genomic alterations associated with sarcomatoid dedifferentiation are poorly characterized. We sought to define the genomic landscape of sRCC and uncover potentially actionable therapeutic targets. We assessed the genomic landscape of sRCC using targeted panel sequencing including patients with microdissected sarcomatoid and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Renal Cell
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hippo Signaling Pathway

Share to Kidney Neoplasms

Share to Laser Capture Microdissection

Share to Neoplasm Transplantation

Share to Neurofibromin 2

Share to YAP-Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 31959902
DOI: 10.1038/s41598-020-57534-5
PMCID: PMC6971072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers.PMID 31959902Read ↗

Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape.Semantic proximity Read ↗

Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets.Semantic proximity Read ↗

Biallelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney.Semantic proximity Read ↗

Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma.Semantic proximity Read ↗

Renal cell tumors with clear cell histology and intact VHL and chromosome 3p: a histological review of tumors from the Cancer Genome Atlas database.Semantic proximity Read ↗

Recent progress in non-clear cell renal cell carcinoma: biology and therapeutic strategiesSemantic proximity Read ↗

Integrated molecular analysis of clear-cell renal cell carcinoma.Semantic proximity Read ↗

Clinical, pathologic, and molecular profiles of sarcomatoid and rhabdoid differentiated clear cell renal cell carcinoma: A series of 21 tumors.Semantic proximity Read ↗

Chromatin accessibility shapes tumor architecture and microenvironment in clear cell renal cell carcinomaSemantic proximity Read ↗

A Zic2/Runx2/NOLC1 signaling axis mediates tumor growth and metastasis in clear cell renal cell carcinomaSemantic proximity Read ↗

Sarcomatoid Renal Cell Carcinoma: The Apple Doesn't Fall Far from the Tree.Semantic proximity Read ↗

Navigating the Current Landscape of Non-Clear Cell Renal Cell Carcinoma: A Review of the LiteratureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.