Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissue and renal cell carcinoma.

doi:10.1093/hmg/ddab031

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Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissue and renal cell carcinoma.

Human molecular genetics - 27 Apr 2021

Laskar Ruhina S, Li Peng, Ecsedi Szilvia, Abedi-Ardekani Behnoush, Durand Geoffroy, Robinot Nivonirina, Hubert Jean-Noël, Janout Vladimir, Zaridze David, Mukeria Anush, Mates Dana, Holcatova Ivana, Foretova Lenka, Swiatkowska Beata, Dzamic Zoran, Milosavljevic Sasa, Olaso Robert, Boland Anne, Deleuze Jean-François, Muller David C, McKay James D, Brennan Paul, Le Calvez-Kelm Florence, Scelo Ghislaine, Chanudet Estelle

Abstract excerpt

Sexual dimorphism in cancer incidence and outcome is widespread. Understanding the underlying mechanisms is fundamental to improve cancer prevention and clinical management. Sex disparities are particularly striking in kidney cancer: across diverse populations, men consistently show unexplained 2-fold increased incidence and worse prognosis. We have characterized genome-wide expression and regulatory networks of...

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Identifiers

PMID: 33527138
DOI: 10.1093/hmg/ddab031
PMCID: PMC8098110

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