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Article

PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

20 Aug 2019

Abstract excerpt

Transcription factor networks shape the gene expression programs responsible for normal cell identity and pathogenic state. Using Core Regulatory Circuitry analysis (CRC), we identify PAX8 as a candidate oncogene in Renal Cell Carcinoma (RCC) cells. Validation of large-scale functional genomic screens confirms that PAX8 silencing leads to decreased proliferation of RCC cell lines. Epigenomic analyses of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31431624
DOI: 10.1038/s41467-019-11672-1

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