Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-A*03, the hemochromatosis ancestral haplotype, and phenotypes of referred hemochromatosis probands with HFE p.C282Y homozygosity.

Hereditas - 6 Jun 2022

Barton James C, Barton J Clayborn, Acton Ronald T

Abstract excerpt

BACKGROUND: Human leukocyte antigen (HLA)-A*03, hemochromatosis ancestral haplotype marker, was associated with greater iron overload in hemochromatosis cohorts reported before discovery of the HFE gene. We sought to learn whether an A*03-linked locus influences phenotypes in referred HFE p.C282Y homozygotes. METHODS: We tabulated these phenotypes in probands with p.C282Y homozygosity: age, transferrin saturation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to Hemochromatosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hemochromatosis Protein

Share to Histocompatibility Antigens Class I

Share to HLA-A Antigens

Share to Homozygote

Share to Iron Overload

Share to Membrane Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 35659379
DOI: 10.1186/s41065-022-00237-w
PMCID: PMC9169309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-A*03, the hemochromatosis ancestral haplotype, and phenotypes of referred hemochromatosis probands with HFE p.C282Y homozygosity.PMID 35659379Read ↗

HLA haplotype A*03-B*07 in hemochromatosis probands with HFE C282Y homozygosity: frequency disparity in men and women and lack of association with severity of iron overloadSemantic proximity Read ↗

Haemochromatosis-associated HFE genotypes in English blood donors: age-related frequency and biochemical expression.Semantic proximity Read ↗

HFE-associated hereditary hemochromatosis: overview of genetics and clinical implications for nurse practitioners in primary care settings.Semantic proximity Read ↗

Iron loading in HFE p.C282Y homozygotes found by population screening: relationships to HLA-type and T-lymphocyte subsets.Semantic proximity Read ↗

Genetic and lifestyle modifiers of haemochromatosis-related clinical outcomes in HFE C282Y homozygotes: prospective cohort study in UK BiobankSemantic proximity Read ↗

Revisiting hemochromatosis: genetic vs. phenotypic manifestationsSemantic proximity Read ↗

Hemochromatosis genotypes and risk of iron overload--a meta-analysis.Semantic proximity Read ↗

Hereditary hemochromatosis: insights from the Hemochromatosis and Iron Overload Screening (HEIRS) Study.Semantic proximity Read ↗

A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload.Semantic proximity Read ↗

Differences in hepatic phenotype between hemochromatosis patients with HFE C282Y homozygosity and other HFE genotypes.Semantic proximity Read ↗

HFE gene and hereditary hemochromatosis: a HuGE review. Human Genome Epidemiology.Semantic proximity Read ↗

Iron overload phenotypes and HFE genotypes in white hemochromatosis and iron overload screening study participants without HFE p.C282Y/p.C282Y.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.