Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haemochromatosis-associated HFE genotypes in English blood donors: age-related frequency and biochemical expression.

Journal of hepatology - 1 Dec 2003

Chambers Vanessa, Sutherland Lindsey, Palmer Karren, Dalton Ann, Rigby Alan S, Sokol Robert, Pollitt Rodney, Tanner Stuart, Gleeson Dermot

Abstract excerpt

BACKGROUND/AIMS: There are limited data on the frequency and biochemical expression of the haemochromatosis-associated mutations C282Y and H63D in healthy people. METHODS: We genotyped (bi-directional PCR amplification of specific alleles method) and performed serum iron studies in randomly selected English male blood donors (<4 previous units donated) in four age bands <30, 30-40, 40-50 and >50 years. RESULTS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Distribution
Share to Blood Donors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to England

Share to Ferritins

Share to Hemochromatosis

Share to Hemochromatosis Protein

Share to Histocompatibility Antigens Class I

Source

Identifiers

PMID: 14642607
DOI: 10.1016/s0168-8278(03)00471-9

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haemochromatosis-associated HFE genotypes in English blood donors: age-related frequency and biochemical expression.PMID 14642607Read ↗

Effect of hemochromatosis genotype and lifestyle factors on iron and red cell indices in a community population.Semantic proximity Read ↗

HLA haplotype A*03-B*07 in hemochromatosis probands with HFE C282Y homozygosity: frequency disparity in men and women and lack of association with severity of iron overloadSemantic proximity Read ↗

Genetic predisposition to iron overload: prevalence and phenotypic expression of hemochromatosis-associated HFE-C282Y gene mutation.Semantic proximity Read ↗

Compound heterozygous hemochromatosis genotype predicts increased iron and erythrocyte indices in women.Semantic proximity Read ↗

HFE genotype and parameters of iron metabolism in German first-time blood donors - evidence for an increased transferrin saturation in C282Y heterozygotes.Semantic proximity Read ↗

Heterozygosity for the C282Y mutation in the hemochromatosis gene is associated with increased serum iron, transferrin saturation, and hemoglobin in young women: a protective role against iron deficiency?Semantic proximity Read ↗

HFE Genotype, Ferritin Levels and Transferrin Saturation in Patients with Suspected Hereditary Hemochromatosis.Semantic proximity Read ↗

Frequency and biochemical expression of C282Y/H63D hemochromatosis (HFE) gene mutations in the healthy adult population in Italy.Semantic proximity Read ↗

Prevalence and clinical significance of HFE gene mutations in patients with iron overload.Semantic proximity Read ↗

HLA-A*03, the hemochromatosis ancestral haplotype, and phenotypes of referred hemochromatosis probands with HFE p.C282Y homozygosity.Semantic proximity Read ↗

Population screening for hemochromatosis: a study in 5370 Spanish blood donors.Semantic proximity Read ↗

Uncommon mutations and polymorphisms in the hemochromatosis gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.