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Article

Hemochromatosis genotypes and risk of iron overload--a meta-analysis.

Annals of epidemiology - 1 Jan 2011

Neghina Adriana Maria, Anghel Andrei

Abstract excerpt

PURPOSE: The incomplete phenotypic penetrance of high iron Fe genotypes in relation to hemochromatosis poses a practical problem in the interpretation of the genotyping results by clinicians. We carried out meta-analyses of the associations between hemochromatosis genotypes C282Y/C282Y, C282Y/H63D, C282Y/wild-type, H63D/H63D, H63D/wild-type, versus wild-type/wild-type and iron overload, both provisional (elevated...

Topics

Genotype
Hemochromatosis
Hemochromatosis Protein
Heterozygote
Histocompatibility Antigens Class I
Humans
Iron Overload
Membrane Proteins
Mutation, Missense
Odds Ratio
Risk

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20800508
DOI: 10.1016/j.annepidem.2010.05.013

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