Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for a mouse origin of the SARS-CoV-2 Omicron variant.

Journal of genetics and genomics = Yi chuan xue bao - 1 Dec 2021

Wei Changshuo, Shan Ke-Jia, Wang Weiguang, Zhang Shuya, Huan Qing, Qian Wenfeng

Abstract excerpt

The rapid accumulation of mutations in the SARS-CoV-2 Omicron variant that enabled its outbreak raises questions as to whether its proximal origin occurred in humans or another mammalian host. Here, we identified 45 point mutations that Omicron acquired since divergence from the B.1.1 lineage. We found that the Omicron spike protein sequence was subjected to stronger positive selection than that of any reported...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to COVID-19
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

Share to Host Specificity

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 34954396
DOI: 10.1016/j.jgg.2021.12.003
PMCID: PMC8702434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for a mouse origin of the SARS-CoV-2 Omicron variant.PMID 34954396Read ↗

Evidence for a mouse origin of the SARS-CoV-2 Omicron variantSemantic proximity Read ↗

Origin and evolutionary analysis of the SARS-CoV-2 Omicron variantSemantic proximity Read ↗

Spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory miceSemantic proximity Read ↗

Spike Protein-independent Attenuation of SARS-CoV-2 Omicron Variant in Laboratory MiceSemantic proximity Read ↗

The Truth about the Origin of OmicronSemantic proximity Read ↗

On the origin of Omicron’s unique Spike gene insertionSemantic proximity Read ↗

Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y.Semantic proximity Read ↗

Analysis of SARS-CoV-2 omicron mutations that emerged during long-term replication in a lung cancer xenograft mouse model.Semantic proximity Read ↗

SARS-CoV-2 Evolution: On the Sudden Appearance of the Omicron Variant.Semantic proximity Read ↗

SARS‐CoV‐2 Omicron emergence urges for reinforced One‐Health surveillanceSemantic proximity Read ↗

In Vitro and Viral Evolution Convergence Reveal the Selective Pressures Driving Omicron EmergenceSemantic proximity Read ↗

Broader-species receptor binding and structural bases of Omicron SARS-CoV-2 to both mouse and palm-civet ACE2sSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.