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Article

Meta-analysis confirmed genetic susceptibility conferred by multiple risk variants from CTLA4 and SERPINA1 in granulomatosis with polyangiitis.

International journal of rheumatic diseases - 1 Jul 2022

Banerjee Pratibha, Kumar Uma, Khetarpal Preeti, Senapati Sabyasachi

Abstract excerpt

BACKGROUND: Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease. Smaller sample size and complex nature of the disease pathogenesis has made it challenging to perform well-powered genetic investigations. We performed a systematic review based meta-analysis in GPA to investigate the genetic susceptibility conferred by non-human leukocyte antigen (non-HLA) candidate genes. METHODS: A...

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PMID: 35656856
DOI: 10.1111/1756-185X.14354

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