Article
Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis.
Arthritis and rheumatism - 1 Oct 2012
Chung Sharon A, Xie Gang, Roshandel Delnaz, Sherva Richard, Edberg Jeffrey C, Kravitz Megan, Dellaripa Paul F, Hoffman Gary S, Mahr Alfred D, Seo Philip, Specks Ulrich, Spiera Robert F, St Clair E William, Stone John H, Plenge Robert M, Siminovitch Katherine A, Merkel Peter A, Monach Paul A
Abstract excerpt
OBJECTIVE: To examine the association of previously identified autoimmune disease susceptibility loci with granulomatosis with polyangiitis (Wegener's) (GPA), and to determine whether the genetic susceptibility profiles of other autoimmune diseases are associated with those of GPA. METHODS: Genetic data from 2 cohorts were meta-analyzed. Genotypes for 168 previously identified single-nucleotide polymorphisms...
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