Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis.

Rheumatology (Oxford, England) - 1 Feb 2015

Watts Richard A, MacGregor Alex J, Mackie Sarah L

Abstract excerpt

OBJECTIVE: Granulomatosis with polyangiitis (GPA) is a rare autoimmune systemic vasculitis considered to result from the interaction of environmental factors with a genetically predisposed host. The HLA-DPB1*0401 allele, the PI*Z allele of the gene encoding α1-antitrypsin (SERPINA1) and the proteinase 3 (PRTN3) gene have been associated with GPA. The incidence of GPA is lower in non-Caucasian populations and has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Frequency
Share to Genetic Variation
Share to Geography, Medical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Global Health

Share to Granulomatosis with Polyangiitis

Share to HLA-DP beta-Chains

Share to Incidence

Share to Multivariate Analysis

Source

Identifiers

PMID: 25172939
DOI: 10.1093/rheumatology/keu321

Genes

PRTN3
SERPINA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis.PMID 25172939Read ↗

Meta-analysis confirmed genetic susceptibility conferred by multiple risk variants from CTLA4 and SERPINA1 in granulomatosis with polyangiitis.Semantic proximity Read ↗

Familial granulomatosis with polyangiitis: three cases of this rare disorder in one Indoasian family carrying an identical HLA DPB1 allele.Semantic proximity Read ↗

SERPINA1 Gene Variants in Granulomatosis with Polyangiitis.Semantic proximity Read ↗

HLA sequencing identifies novel associations and suggests clinical relevance of DPB1*04:01 in ANCA-associated Granulomatosis with polyangiitis.Semantic proximity Read ↗

A shared motif of hla-dpb1 affecting the susceptibility to pr3-anca positive granulomatosis with polyangiitis: comparative analysis of a Turkish cohort with matched healthy controls.Semantic proximity Read ↗

[Genetic risk factors for vasculitis].Semantic proximity Read ↗

Genetics of ANCA-associated vasculitides: HLA and beyond.Semantic proximity Read ↗

Genetics and pathophysiology of granulomatosis with polyangiitis (GPA) and its main autoantigen proteinase 3.Semantic proximity Read ↗

Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.Semantic proximity Read ↗

Genetic associations of eosinophilic granulomatosis with polyangiitis in the Japanese population: Exploring similarities and differences with European populationsSemantic proximity Read ↗

Is granulomatosis with polyangiitis in Asia different from the West?Semantic proximity Read ↗

Distinct HLA and non-HLA associations in different subtypes of ANCA-associated vasculitides in North India.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.