Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.

doi:10.1136/ard-2022-223697

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Article

Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.

Annals of the rheumatic diseases - 1 Jun 2023

Ortiz-Fernández Lourdes, Carmona Elio G, Kerick Martin, Lyons Paul, Carmona Francisco David, López Mejías Raquel, Khor Chiea Chuen, Grayson Peter C, Tombetti Enrico, Jiang Lindi, Direskeneli Haner, Saruhan-Direskeneli Guher, Callejas-Rubio José-Luis, Vaglio Augusto, Salvarani Carlo, Hernández-Rodríguez Jose, Cid Maria Cinta, Morgan Ann W, Merkel Peter A, Burgner David, Smith Kenneth Gc, Gonzalez-Gay Miguel Angel, Sawalha Amr H, Martin Javier, Marquez Ana

Abstract excerpt

OBJECTIVES: The number of susceptibility loci currently associated with vasculitis is lower than in other immune-mediated diseases due in part to small cohort sizes, a consequence of the low prevalence of vasculitides. This study aimed to identify new genetic risk loci for the main systemic vasculitides through a comprehensive analysis of their genetic overlap. METHODS: Genome-wide data from 8467 patients with...

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Identifiers

PMID: 36797040
DOI: 10.1136/ard-2022-223697
PMCID: PMC10314028

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