NF‐κB ‐dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cells

Abstract excerpt

Abstract Cellular senescence is characterized by a stable proliferation arrest in response to stresses and the acquisition of a senescence‐associated secretory phenotype, called SASP, composed of numerous factors including pro‐inflammatory molecules, proteases, and growth factors. The SASP affects the environment of senescent cells, especially during aging, by inducing and modulating various phenotypes such as...

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