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Slicer Endonuclease Argonaute 2 Is a Negative Regulator of Hematopoietic Stem Cell Quiescence.

Stem cells (Dayton, Ohio) - 1 May 2016

Lu Kenneth, Nakagawa Masahiro Marshall, Thummar Keyur, Rathinam Chozha Vendan

Abstract excerpt

Hematopoietic stem cells (HSCs) are capable of both self-renewing throughout the lifetime of an organism and differentiating into all lineages of the blood system. A proper balance between quiescence and proliferation is critical for the self-renewal and functions of HSCs. The choice of HSCs to remain quiescent or to enter proliferation has been tightly regulated by a variety of cell intrinsic and extrinsic...

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PMID: 26850790
DOI: 10.1002/stem.2302

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