Transient stabilization of human cardiovascular progenitor cells from human pluripotent stem cells in vitro reflects stage-specific heart development in vivo.

doi:10.1093/cvr/cvae118

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Transient stabilization of human cardiovascular progenitor cells from human pluripotent stem cells in vitro reflects stage-specific heart development in vivo.

Cardiovascular research - 21 Sept 2024

Bolesani Emiliano, Bornhorst Dorothee, Iyer Lavanya M, Zawada Dorota, Friese Nina, Morgan Michael, Lange Lucas, Gonzalez David M, Schrode Nadine, Leffler Andreas, Wunder Julian, Franke Annika, Drakhlis Lika, Sebra Robert, Schambach Axel, Goedel Alexander, Dubois Nicole C, Dobreva Gergana, Moretti Alessandra, Zelaráyan Laura C, Abdelilah-Seyfried Salim, Zweigerdt Robert

Abstract excerpt

AIMS: Understanding the molecular identity of human pluripotent stem cell (hPSC)-derived cardiac progenitors and mechanisms controlling their proliferation and differentiation is valuable for developmental biology and regenerative medicine. METHODS AND RESULTS: Here, we show that chemical modulation of histone acetyl transferases (by IQ-1) and WNT (by CHIR99021) synergistically enables the transient and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heart

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeobox Protein Nkx-2.5

Share to LIM-Homeodomain Proteins

Share to Myocytes, Cardiac

Share to Myocytes, Smooth Muscle

Share to Pyridines

Share to Single-Cell Analysis

Share to Wnt Signaling Pathway

Source

Open in PubMed

Identifiers

PMID: 38836637
DOI: 10.1093/cvr/cvae118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transient stabilization of human cardiovascular progenitor cells from human pluripotent stem cells in vitro reflects stage-specific heart development in vivo.PMID 38836637Read ↗

Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitmentSemantic proximity Read ↗

Primitive Cardiac Cells from Human Embryonic Stem CellsSemantic proximity Read ↗

In Vitro Epigenetic Reprogramming of Human Cardiac Mesenchymal Stromal Cells into Functionally Competent Cardiovascular PrecursorsSemantic proximity Read ↗

Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiationSemantic proximity Read ↗

Combined Lineage Tracing and scRNA-seq Reveals Unexpected First Heart Field Predominance of Human iPSC DifferentiationSemantic proximity Read ↗

Fate of developmental mechanisms of myocardial plasticity in the postnatal heartSemantic proximity Read ↗

The level of HAND1 controls the specification of multipotent cardiac and extraembryonic progenitorsSemantic proximity Read ↗

Generation of Heart Organoids Modeling Early Human Cardiac Development Under Defined ConditionsSemantic proximity Read ↗

Genetic and Epigenetic Regulation of Cardiac Development: An Integrative View from Embryo to Human Pluripotent Stem Cell ModelsSemantic proximity Read ↗

Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitmentSemantic proximity Read ↗

Human Embryonic Stem Cell Derived Mesenchymal Progenitors Express Cardiac Markers but Do Not Form Contractile CardiomyocytesSemantic proximity Read ↗

Efficient Derivation of Human Cardiac Precursors and Cardiomyocytes from Pluripotent Human Embryonic Stem Cells with Small Molecule InductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.