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An Arabidopsis pre-RNA processing8a (prp8a) missense allele restores splicing of a subset of mis-spliced mRNAs.

Plant physiology - 1 Aug 2022

Llinas Roxanna J, Xiong Jia Qi, Clark Natalie M, Burkhart Sarah E, Bartel Bonnie

Abstract excerpt

Eukaryotic precursor mRNAs often harbor noncoding introns that must be removed prior to translation. Accurate splicing of precursor messenger RNA depends on placement and assembly of small nuclear ribonucleoprotein (snRNP) sub-complexes of the spliceosome. Yeast (Saccharomyces cerevisiae) studies established a role in splice-site selection for PRE-RNA PROCESSING8 (PRP8), a conserved spliceosome scaffolding...

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PMID: 35608297
DOI: 10.1093/plphys/kiac221
PMCID: PMC9342983

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