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Integrated analysis of somatic mutations and immune microenvironment in malignant pleural mesothelioma

6 Jan 2017

Abstract excerpt

To investigate the link between the genomic landscape of cancer cells and immune microenvironment in tumor tissues, we characterized somatic mutations and tumor-infiltrating lymphocytes (TILs) in malignant pleural mesothelioma (MPM), including mutation/neoantigen load, spatial heterogeneity of somatic mutations of cancer cells and TILs (T-cell receptor β (TCRβ) repertoire), and expression profiles of...

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PMID: 28344893
DOI: 10.1080/2162402x.2016.1278330

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