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Article

A review of methods for the reconstruction and analysis of integrated genome-scale models of metabolism and regulation.

Biochemical Society transactions - 30 Oct 2020

Cruz Fernando, Faria José P, Rocha Miguel, Rocha Isabel, Dias Oscar

Abstract excerpt

The current survey aims to describe the main methodologies for extending the reconstruction and analysis of genome-scale metabolic models and phenotype simulation with Flux Balance Analysis mathematical frameworks, via the integration of Transcriptional Regulatory Networks and/or gene expression data. Although the surveyed methods are aimed at improving phenotype simulations obtained from these models, the...

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PMID: 32940659
DOI: 10.1042/BST20190840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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