Reconstructing organisms in silico: genome-scale models and their emerging applications.

doi:10.1038/s41579-020-00440-4

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Article

Reconstructing organisms in silico: genome-scale models and their emerging applications.

Nature reviews. Microbiology - 1 Dec 2020

Fang Xin, Lloyd Colton J, Palsson Bernhard O

Abstract excerpt

Escherichia coli is considered to be the best-known microorganism given the large number of published studies detailing its genes, its genome and the biochemical functions of its molecular components. This vast literature has been systematically assembled into a reconstruction of the biochemical reaction networks that underlie E. coli's functions, a process which is now being applied to an increasing number of...

Topics

Actinobacteria
Computer Simulation
Cyanobacteria
Escherichia coli
Firmicutes
Gene Regulatory Networks
Genome, Bacterial
Genomics
Metabolic Networks and Pathways
Models, Genetic
Phenotype
Proteobacteria
Stress, Physiological
Thermotoga
Whole Genome Sequencing

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Identifiers

PMID: 32958892
DOI: 10.1038/s41579-020-00440-4
PMCID: PMC7981288

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