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Article

Genetic Architecture of Plasma Alpha-Aminoadipic Acid Reveals a Relationship With High-Density Lipoprotein Cholesterol.

Journal of the American Heart Association - 7 Jun 2022

Shi Mingjian, Wang Chuan, Mei Hao, Temprosa Marinella, Florez Jose C, Tripputi Mark, Merino Jordi, Lipworth Loren, Shu Xiao-Ou, Gerszten Robert E, Wang Thomas J, Beckman Joshua A, Gamboa Jorge L, Mosley Jonathan D, Ferguson Jane F

Abstract excerpt

Background Elevated plasma levels of alpha-aminoadipic acid (2-AAA) have been associated with the development of type 2 diabetes and atherosclerosis. However, the nature of the association remains unknown. Methods and Results We identified genetic determinants of plasma 2-AAA through meta-analysis of genome-wide association study data in 5456 individuals of European, African, and Asian ancestry from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35621206
DOI: 10.1161/JAHA.121.024388
PMCID: PMC9238724

Genes

DHTKD1
MSR1
NDUFS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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