Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation.

Diabetes care - 1 Dec 2017

Wang Qin, Holmes Michael V, Davey Smith George, Ala-Korpela Mika

Abstract excerpt

OBJECTIVE: Insulin resistance has deleterious effects on cardiometabolic disease. We used Mendelian randomization analyses to clarify the causal relationships of insulin resistance (IR) on circulating blood-based metabolites to shed light on potential mediators of the IR to cardiometabolic disease relationship. RESEARCH DESIGN AND METHODS: We used 53 single nucleotide polymorphisms associated with IR from a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiposity
Share to Amino Acids, Branched-Chain
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Insulin

Share to Insulin Resistance

Share to Mendelian Randomization Analysis

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 29046328
DOI: 10.2337/dc17-1642
PMCID: PMC5701741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation.PMID 29046328Read ↗

Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization studySemantic proximity Read ↗

Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels.Semantic proximity Read ↗

Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes.Semantic proximity Read ↗

The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review.Semantic proximity Read ↗

Relationship between branched chain amino acids and type 2 diabetes: a bidirectional Mendelian Randomization studySemantic proximity Read ↗

The causal associations of circulating amino acids with blood pressure: a Mendelian randomization study.Semantic proximity Read ↗

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.Semantic proximity Read ↗

Causal relationships of circulating amino acids with cardiovascular disease: a trans-ancestry Mendelian randomization analysis.Semantic proximity Read ↗

Association of Circulating Branched-Chain Amino Acids with Cardiovascular Diseases: A Mendelian Randomization Study.Semantic proximity Read ↗

Causal relationships between genetically predicted circulating levels of amino acids and non-alcoholic fatty liver disease risk: a Mendelian randomisation studySemantic proximity Read ↗

Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight ChangeSemantic proximity Read ↗

Prioritising determinants of systemic inflammation across molecular, physiological and disease phenotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.