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Article

Mendelian Randomization Study on Amino Acid Metabolism Suggests Tyrosine as Causal Trait for Type 2 Diabetes.

Nutrients - 19 Dec 2020

Jäger Susanne, Cuadrat Rafael, Wittenbecher Clemens, Floegel Anna, Hoffmann Per, Prehn Cornelia, Adamski Jerzy, Pischon Tobias, Schulze Matthias B

Abstract excerpt

Circulating levels of branched-chain amino acids, glycine, or aromatic amino acids have been associated with risk of type 2 diabetes. However, whether those associations reflect causal relationships or are rather driven by early processes of disease development is unclear. We selected diabetes-related amino acid ratios based on metabolic network structures and investigated causal effects of these ratios and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33352682
DOI: 10.3390/nu12123890
PMCID: PMC7766372

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