Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of circulating branched-chain or aromatic amino acids based on metabolome and apolipoprotein E genotype with incident dementia: a large cohort study.

International journal of food sciences and nutrition - 1 May 2026

Liu Ziwei, Ai Yongjun, Wu Yue, Zhang Yuncheng, Hua Jianian, Liu Tong, Liu Dong, Chen Guo-Chong, Xu Guangfei, Chen Li-Hua

Abstract excerpt

The associations between branched-chain amino acids (BCAAs) and dementia in individuals with chronic diseases remain unclear, and evidence on aromatic amino acids (AAAs) is limited. Using metabolic biomarker data from 117,892 UK Biobank participants, we found that higher circulating levels of BCAAs (HR=0.56, 95% CI: 0.41-0.76) and AAAs (HR=0.74, 95% CI: 0.55-0.98) were associated with lower risks of all-cause...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amino Acids, Aromatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amino Acids, Branched-Chain

Share to Apolipoproteins E

Share to Biomarkers

Share to Cohort Studies

Share to Dementia

Share to Metabolome

Source

Identifiers

PMID: 41942124
DOI: 10.1080/09637486.2026.2649766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of circulating branched-chain or aromatic amino acids based on metabolome and apolipoprotein E genotype with incident dementia: a large cohort study.PMID 41942124Read ↗

Metabolomic ageing (MileAge) in mid-life predicts incident vascular, unspecified and all-cause dementia.Semantic proximity Read ↗

Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition: a validation studySemantic proximity Read ↗

Investigating the causal association between branched-chain amino acids and Alzheimer's disease: A bidirectional Mendelian randomized studySemantic proximity Read ↗

Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition and energy metabolism – A validation studySemantic proximity Read ↗

Higher dietary advanced glycation products intake is associated with increased risk of dementia, independent from genetic predisposition.Semantic proximity Read ↗

Accelerated metabolomic ageing (MileAge) in mid-life predicts incident vascular, unspecified and all-cause dementiaSemantic proximity Read ↗

Differences in Plasma Metabolites Related to Alzheimer’s Disease, APOE-ε4 status and EthnicitySemantic proximity Read ↗

The Metabolite Profiles of the Obese Population Are Gender-DependentSemantic proximity Read ↗

Early Metabolic Alterations in Cerebrospinal Fluid Fatty Acid Profiles Linked to Cognitive Decline and All-Cause DementiaSemantic proximity Read ↗

The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review.Semantic proximity Read ↗

Circulating Metabolites are Linked to Dementia and Brain Imaging Phenotypes, and Mediate Modifiable Risk PathwaysSemantic proximity Read ↗

Towards understanding brain-gut-microbiome connections in Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.