SGLT2 inhibition, high-density lipoprotein cholesterol and aortic aneurysm: A drug-target Mendelian randomization study.

doi:10.1016/j.numecd.2026.104701

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SGLT2 inhibition, high-density lipoprotein cholesterol and aortic aneurysm: A drug-target Mendelian randomization study.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Aug 2026

Song Zheng-Qi, Pei Yan-Zhen, Wu Sheng-Ke, Chen Xiu-Xiu, Chen Yi-He

Abstract excerpt

BACKGROUND AND AIM: The causal effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on aortic aneurysm (AA), as well as the underlying lipid metabolism, remain largely unexplored. METHODS AND RESULTS: We extracted genetic variants within the cis-region of the SLC5A2 gene from the genome-wide association study of hemoglobin A1c (HbA1c) to proxy the effects of SGLT2 inhibition. Two-sample Mendelian...

Topics

Humans
Mendelian Randomization Analysis
Diabetes Mellitus, Type 2
Sodium-Glucose Transporter 2 Inhibitors
Biomarkers
Sodium-Glucose Transporter 2
Risk Factors
Cholesterol, HDL
Risk Assessment
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycated Hemoglobin

Aortic Aneurysm

Pharmacogenomic Variants

Phenotype

Treatment Outcome

Protective Factors

Polymorphism, Single Nucleotide

Blood Glucose

Source

Open in PubMed

Identifiers

PMID: 41963232
DOI: 10.1016/j.numecd.2026.104701

Genes

SLC5A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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