Article
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance.
Genes & development - 1 May 2022
Yin Kelvin, Patten Daniel, Gough Sarah, de Barros Gonçalves Susana, Chan Adelyne, Olan Ioana, Cassidy Liam, Poblocka Marta, Zhu Haoran, Lun Aaron, Schuijs Martijn, Young Andrew, Martinez-Jimenez Celia, Halim Timotheus Y F, Shetty Shishir, Narita Masashi, Hoare Matthew
Abstract excerpt
Senescence is a stress-responsive tumor suppressor mechanism associated with expression of the senescence-associated secretory phenotype (SASP). Through the SASP, senescent cells trigger their own immune-mediated elimination, which if evaded leads to tumorigenesis. Senescent parenchymal cells are separated from circulating immunocytes by the endothelium, which is targeted by microenvironmental signaling. Here we...
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