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Article

Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

27 Mar 2023

Abstract excerpt

Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated in many age-related diseases. Here, we investigated the expression and function of the immunomodulatory cytokine BAFF (B-cell activating factor; encoded by the...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 37083495
DOI: 10.7554/elife.84238

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