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Article

Chemotherapy-derived DAMPs drive reprogramming of tumor-associated macrophages toward a pro-inflammatory phenotype in hepatocellular carcinoma.

Scientific reports - 3 Apr 2026

Songjang Worawat, Paiyabhroma Nitchawat, Srisuwan Chiranan, Promchai Samitanan, Nensat Chatchai, Pankhong Panyupa, Kumphune Sarawut, Jiraviriyakul Arunya

Abstract excerpt

Hepatocellular carcinoma (HCC) remains a global health challenge, with treatment efficacy often compromised by the immunosuppressive tumor microenvironment (TME), particularly tumor-associated macrophages (TAMs). While chemotherapy induces immunogenic cell death (ICD) and the release of Damage-Associated Molecular Patterns (DAMPs), the specific impact of these molecules on macrophage plasticity and the underlying...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41933190
DOI: 10.1038/s41598-026-47480-z
PMCID: PMC13237232

Genes

NLRP3
CD163
CD86
HMGB1
S100A9
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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