Article
Absence of NOTCH1 mutation and presence of CDKN2A deletion predict progression of esophageal lesions.
The Journal of pathology - 1 Sept 2022
Liu Mengfei, Liu Ying, Zhou Ren, Liu Zhen, Guo Chuanhai, Xu Ruiping, Li Fenglei, Liu Anxiang, Yang Haijun, Zhang Sanshen, Shen Lin, Duan Liping, Wu Qi, Zhao Meng, Su Hong, Liu Fangfang, Pan Yaqi, Cai Hong, He Zhonghu, Ke Yang
Abstract excerpt
Currently, surveillance for esophageal squamous cell carcinoma (ESCC) runs a risk of underestimation of early lesions which show absence of iodine staining, with no or only mild histologic changes. The development of molecular markers that indicate risk of progression is thus warranted. We performed whole-exome sequencing on biopsies from two sequential endoscopies of a single esophageal lesion and matching blood...
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