New insights into the genetic progression of cancer through longitudinal analysis of oral lesions.

doi:10.1002/path.6449

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Article

New insights into the genetic progression of cancer through longitudinal analysis of oral lesions.

The Journal of pathology - 1 Oct 2025

Wils Leon J, Poell Jos B, Brink Arjen, Peferoen Laura An, Evren Ilkay, Brouns Elisabeth R, de Visscher Jan Gam, van der Meij Erik H, Bloemena Elisabeth, Brakenhoff Ruud H

Abstract excerpt

Genetic progression models of cancer continue to determine the roadmap of carcinogenesis, although the sequence of genetic events is inferred rather than empirically determined through longitudinal analyses. Here, we present a unique longitudinal study of oral leukoplakia lesions that transformed into carcinoma. Lesions were followed from initial diagnosis through to malignant transformation. For each lesion,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40728388
DOI: 10.1002/path.6449
PMCID: PMC12438000

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