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Article

Neuroendocrine transformation from EGFR/ALK-wild type or TKI-naïve non-small cell lung cancer: An under-recognized phenomenon.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2022

Chu Xiao, Xu Yuyin, Li Ye, Zhou Yue, Chu Li, Yang Xi, Ni Jianjiao, Li Yida, Guo Tiantian, Zheng Zhiqin, Zheng Qiang, Yao Qianlan, Li Yuan, Zhou Xiaoyan, Zhu Zhengfei

Abstract excerpt

INTRODUCTION: Neuroendocrine transformation (NET) is a resistance mechanism for epidermal growth factor receptor (EGFR)/anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). We aimed to elucidate whether NET develops in TKI-naïve NSCLC by using molecular fingerprinting in paired pre- and post-NET tissues. PATIENTS AND METHODS: NET cases were identified based on...

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PMID: 35609408
DOI: 10.1016/j.lungcan.2022.05.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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