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Article

Histological transformation in lung cancer: a single-arm meta-analysis and systematic review.

BMC cancer - 21 May 2026

Hu Lefei, Zhu Xunxia, Chen Xiaoyu, Yang Fuzhi, Jiang Shuai, Guo Shixiang, Wei Mingfeng, Li Zheng, Shen Xiaoyong

Abstract excerpt

BACKGROUND: Histological transformation represents an important mechanism of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in EGFR-mutant lung cancer; however, its incidence, timing, and post-transformation outcomes remain incompletely characterized. METHODS: We conducted a systematic review and meta-analysis in accordance with PRISMA guidelines and Cochrane...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to ErbB Receptors

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Source

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Identifiers

PMID: 42163145
DOI: 10.1186/s12885-026-16114-y
PMCID: PMC13366735

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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