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Article

Histological transformation after acquired resistance to epidermal growth factor tyrosine kinase inhibitors.

International journal of clinical oncology - 1 Apr 2018

Shao Yi, Zhong Dian-Sheng

Abstract excerpt

Non-small-cell lung cancer patients with sensitive epidermal growth factor receptor mutations generally respond well to tyrosine kinase inhibitors (TKIs). However, acquired resistance will eventually develop place after 8-16 months. Several mechanisms contribute to the resistance including T790M mutation, c-Met amplification, epithelial mesenchymal transformation and PIK3CA mutation; however, histological...

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Source

Identifiers

PMID: 29110101
DOI: 10.1007/s10147-017-1211-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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