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Article

Authentic neuroendocrine transdifferentiation from lung adenocarcinoma to small-cell lung cancer: a case report.

BMC pulmonary medicine - 12 Mar 2026

Li Mengqian, Zhou Ping, Wu Xuexue, Jiang Lili

Abstract excerpt

BACKGROUND: Reports of small-cell lung cancer (SCLC) transdifferentiation in epidermal growth factor receptor tyrosine (EGFR)‑mutant lung adenocarcinoma (LUAD) often reflect pre‑existing combined SCLC or are limited by sampling bias, obscuring true treatment‑induced lineage transformation. CASE PRESENTATION: We report a female patient with EGFR‑mutant LUAD who, during EGFR tyrosine kinase inhibitor therapy,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41820948
DOI: 10.1186/s12890-026-04180-8
PMCID: PMC13093959

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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