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Donor T cell DNMT3a regulates alloreactivity in mouse models of hematopoietic stem cell transplantation

24 May 2022

Abstract excerpt

DNA methyltransferase 3a (DNMT3a) is an important part of the epigenetic machinery that stabilizes patterns of activated T cell responses. We hypothesized that donor T cell DNMT3a regulates alloreactivity after allogeneic blood and marrow transplantation (allo-BMT). T cell conditional Dnmt3a KO mice were used as donors in allo-BMT models. Mice receiving allo-BMT from KO donors developed severe acute...

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PMID: 35608905
DOI: 10.1172/jci158047

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