Article
Detecting genetic epistasis by differential departure from independence.
Molecular genetics and genomics : MGG - 1 Jul 2022
Sharma Ruby, Sadeghian Tehrani Zeinab, Kumar Sajal, Song Mingzhou
Abstract excerpt
Countering prior beliefs that epistasis is rare, genomics advancements suggest the other way. Current practice often filters out genomic loci with low variant counts before detecting epistasis. We argue that this practice is far from optimal because it can throw away strong epistatic patterns. Instead, we present the compensated Sharma-Song test to infer genetic epistasis in genome-wide association studies by...
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