Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice.

doi:10.1016/j.expneurol.2022.114118

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Article

Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice.

Experimental neurology - 1 Sept 2022

Cutia Cathryn A, Leverton Leanna K, Ge Xiyu, Youssef Rana, Raetzman Lori T, Christian-Hinman Catherine A

Abstract excerpt

Clinical evidence indicates that patients with temporal lobe epilepsy (TLE) often show differential outcomes of comorbid conditions in relation to the lateralization of the seizure focus. A particularly strong relationship exists between the side of seizure focus and the propensity for distinct reproductive endocrine comorbidities in women with TLE. Therefore, here we evaluated whether targeting of left or right...

Topics

Animals
Disease Models, Animal
Epilepsy, Temporal Lobe
Female
Hippocampus
Humans
Kainic Acid
Mice
Phenotype
Seizures

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Identifiers

PMID: 35597270
DOI: 10.1016/j.expneurol.2022.114118
PMCID: PMC10462257

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