Sex differences in models of temporal lobe epilepsy: role of testosterone.

doi:10.1016/s0006-8993(02)02691-4

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Article

Sex differences in models of temporal lobe epilepsy: role of testosterone.

Brain research - 19 Jul 2002

Mejías-Aponte Carlos A, Jiménez-Rivera Carlos A, Segarra Annabell C

Abstract excerpt

Kainic acid and pilocarpine were used to assess sex differences in temporal lobe seizures. Adult Sprague-Dawley rats were injected with kainic acid (10-12 mg/kg) or with pilocarpine (380 mg/kg) and behavior was recorded for the next 3 h. Trunk blood was collected for hormonal measurements. Our data indicate that the male is more susceptible to the convulsant effects of agents that produce temporal lobe-like...

Topics

Animals
Behavior, Animal
Brain
Corticosterone
Disease Models, Animal
Epilepsy, Temporal Lobe
Excitatory Amino Acid Agonists
Female
Genetic Predisposition to Disease
Hypothalamo-Hypophyseal System
Kainic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Muscarinic Agonists

Neurons

Pilocarpine

Rats

Rats, Sprague-Dawley

Reaction Time

Source

Open in PubMed

Identifiers

PMID: 12106683
DOI: 10.1016/s0006-8993(02)02691-4

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