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Article

Sex- and Age-Specific Impact of ERK Loss Within the Pituitary Gonadotrope in Mice.

Endocrinology - 1 Mar 2018

Brown Jessica L, Xie Jianjun, Brieño-Enriquez Miguel Angel, Sones Jennifer L, Angulo Cynthia N, Boehm Ulrich, Miller Andrew, Toufaily Chirine, Wang Ying, Bernard Daniel J, Roberson Mark S

Abstract excerpt

Extracellular signal-regulated kinase (ERK) signaling regulates hormone action in the reproductive axis, but specific mechanisms have yet to be completely elucidated. In the current study, ERK1 null and ERK2 floxed mice were combined with a gonadotropin-releasing hormone receptor (GnRHR)-internal ribosomal entry site-Cre (GRIC) driver. Female ERK double-knockout (ERKdko) animals were hypogonadotropic, resulting...

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Identifiers

PMID: 29300908
DOI: 10.1210/en.2017-00653
PMCID: PMC5802804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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