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Subproteomic profiling from renal cortices in OLETF rats reveals mutations of multiple novel genes in diabetic nephropathy.

Genes & genomics - 1 Jan 2022

Li Zhiguo, Shen Hong, Liu Yeqiang, Zhou Xuefeng, Yan Meihua, He Hailan, Zhao Tingting, Zhang Haojun, Li Ping

Abstract excerpt

BACKGROUND: Diabetic nephropathy (DN) is a serious threat to human health, but its pathogenesis is not fully understood. Otsuka Long-Evans Tokushima Fatty (OLETF) rats are very similar to human DN in many aspects such as pathological changes and processes, and are deemed to be an ideal rodent model. OBJECTIVE: This study was aimed to explore the pathogenesis of DN by analyzing the protein expression profile from...

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Share to Diabetes Mellitus, Type 2
Share to Diabetic Nephropathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Two-Dimensional

Share to Kidney

Share to Proteome

Share to Proteomics

Share to Sequence Homology, Amino Acid

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Identifiers

PMID: 34643893
DOI: 10.1007/s13258-021-01174-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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