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Functions of the podocyte proteins nephrin and Neph3 and the transcriptional regulation of their genes

25 Oct 2013

Abstract excerpt

Nephrin and Neph-family proteins [Neph1-3 (nephrin-like 1-3)] belong to the immunoglobulin superfamily of cell-adhesion receptors and are expressed in the glomerular podocytes. Both nephrin and Neph-family members function in cell adhesion and signalling, and thus regulate the structure and function of podocytes and maintain normal glomerular ultrafiltration. The expression of nephrin and Neph3 is altered in...

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PMID: 24219158
DOI: 10.1042/cs20130258

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