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Article

miR‐181b regulates vascular endothelial aging by modulating an MAP3K3 signaling pathway

20 May 2022

Abstract excerpt

Abstract Endothelial cell (EC) aging plays a vital role in the pathogenesis of cardiovascular disease (CVD). MicroRNAs have emerged as crucial regulators of target gene expression by inhibiting mRNA translation and/or promoting mRNA degradation. We identify an aging‐related and oxidative stress‐responsive microRNA, miR‐181b, that inhibits endothelial cell apoptosis and senescence. In gain‐ or loss‐of‐function...

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PMID: 35593587
DOI: 10.1096/fj.202200046r

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