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Article

Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway.

PloS one - 1 Jan 2014

Yoshida Yohko, Hayashi Yuka, Suda Masayoshi, Tateno Kaoru, Okada Sho, Moriya Junji, Yokoyama Masataka, Nojima Aika, Yamashita Masakatsu, Kobayashi Yoshio, Shimizu Ippei, Minamino Tohru

Abstract excerpt

Evolutionarily conserved Notch signaling controls cell fate determination and differentiation during development, and is also essential for neovascularization in adults. Although recent studies suggest that the Notch pathway is associated with age-related conditions, it remains unclear whether Notch signaling is involved in vascular aging. Here we show that Notch signaling has a crucial role in endothelial cell...

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Identifiers

PMID: 24950189
DOI: 10.1371/journal.pone.0100359
PMCID: PMC4065107

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