Article
miR-146a is modulated in human endothelial cell with aging.
Atherosclerosis - 1 Aug 2011
Vasa-Nicotera Mariuca, Chen Hailan, Tucci Paola, Yang Ai Li, Saintigny Gaelle, Menghini Rossella, Mahè Christian, Agostini Massimiliano, Knight Richard A, Melino Gerry, Federici Massimo
Abstract excerpt
BACKGROUND: Increasing evidence has demonstrated that the senescence of vascular endothelial cells has critical roles in the pathogenesis of vascular dysfunction such as atherosclerosis and thrombosis. MicroRNA (miR) are small non-coding RNAs that inhibit gene expression by binding to complementary sequences in the 3'UTR of their target mRNAs. MiRs modulate a variety of biological functions such as cell...
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